School of Medicine and School of Public Health
University of North Carolina at Chapel Hill
Dr. Coleman is an expert in childhood disorders related to genetic problems in metabolism of carbohydrates and lipids, especially, disorders linked to abnormally high lipid levels in the blood. Her lab focuses on studies of energy metabolism in knockout mice as well as in differentiated hepatocytes, myocytes, and fat cells in culture. These studies include glucose and fatty acid use, responses to insulin, and the effects of physiological stresses like fasting, exercise, cold exposure, and high fat diets. Dr. Coleman is particularly interested in the activation of long-chain fatty acids and their partitioning into pathways of complex lipid synthesis versus beta-oxidation. Her laboratory has cloned and characterized novel glycerol-3-phosphate acyltransferases catalyzing the first step in the synthesis of triacylglycerol and phospholipids. Further studies of mice that are deficient in lipid synthetic enzymes have shown the importance of specific isoforms in the development of hepatic steatosis and NASH, diet-induced obesity, and hormonally induced insulin resistance. Recent work from her lab has demonstrated that acyl-CoAs are compartmentalized within cells and that compartmentalization may depend on specific interacting protein partners.
Memorial Sloan Kettering Cancer Center
Dr. Kolesnick is an internationally recognized physician-scientist investigating the role and mechanisms of sphingolipid signaling in stress response, with special focus on stress induced by cancer treatment. Various environmental and pharmacological stressors, such as heat, ionizing radiation, UV light, chemotherapeutic agents, oxidative stress, etc., induce generation of second messenger ceramide which defines whether adaptation or apoptosis ensues in affected cells. Dr. Kolesnick’s laboratory uses a multidisciplinary approach involving genetics, biochemistry and cell biology to determine the mechanistic details of this signaling and learn how to use it in the fight against cancer. His lab has identified radiation-induced ceramide elevation in the tumor vascular endothelial cells as one of the mechanisms of ionizing radiation effects on tumors and continues to investigate mechanisms of radiation-induced cell death. The Kolesnick team has also demonstrated that kinase suppressor of Ras can be activated by ceramide via the direct binding to the protein, and determined the important role of ceramide-rich lipid rafts in transmembrane signaling. Dr. Kolesnick is highly recognized as the authority in sphingolipid biology and the impact of his work is tremendous.
SERLC's uniqueness resides in selecting abstracts submitted by graduate students and post-doctoral fellows for oral and poster presentations, making this meeting a training platform for the next generation of lipid scientists. Abstract merit scoring will be utilized for the selection of many travel awardees.
Please email submissions to
The Southeastern Regional Lipid Conference (SERLC) is one of the largest and most established academic meetings on lipid biology research in the United States. The main themes are sphingolipids, phospholipids, and eicosanoids, their analysis by state of the art lipidomics, and their biological functions in cell signaling, cell biology and in physiological and pathophysiological processes, including metabolic and infectious diseases, immunology and cancer.
Early Registration Deadline is
October 4, 2019.
The winner of the photo contest will have their accommodations covered and their picture featured on the cover of the 2019 SERLC Conference Booklet.
Deadline to submit photos:
October 25, 2019
Please submit entries for the photo contest to:
CHAIR: Natalia Krupenko, Ph.D. Assistant Professor, Department of Nutrition, UNC at Chapel Hill, Natalia_Krupenko@unc.edu
Santiago Lima, Ph.D. Assistant professor, Department of Biology, Virginia Commonwealth University
Jamie Sturgill, Ph.D. Assistant professor, Internal Medicine, University of Kentucky
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