Program

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4:00 pm - 5:30 pm  Arrival and Registration

5:30 pm – 6:30 pm  Welcome Reception (Pisgah & Pilot)

6:30 pm - 7:30 pm  Dinner (Pisgah & Pilot)

7:45 pm – 7:55 pm  Opening Remarks (Mitchell & Roan)

Santiago Lima, VCU

7:55 pm – 8:00 pm  Remarks for the ASBMB Lipid Research Division Seminar   Series Award 

Ray Blind, Vanderbilt University

8:00 pm – 9:00 pm Keynote Presentation 

Thomas P. Loughran Jr., MD, University of Virginia

Title: Dysregulated Sphingolipid Metabolism in Leukemia

9:00 pm – 11:00 pm  Social Time and Preliminary Poster Viewing (Pisgah & Pilot).

7:00 am - 8:00 am Breakfast (Pisgah & Pilot)

8:00 am – 10:00 am Oral Session I (Mitchell & Roan)

Lipid Biochemistry and Structural Biology

Session Chairs: Ahmed Elsherbini and Kerri Barron

8:05 am The transport mechanism of Neo1, a monomeric P4-ATPase lipid flippase. Jain B.K., Bai L., You Q., Duan H.D., Takar M., Li H., Graham T.R. 

8:20 am Manipulation of the sphingolipid pathway promotes ER stress tolerance in a yeast model of ALS8. Rimal A. and Prosser DC. 

8:35 am Phosphoinositides in the Hippo pathway: PI5P binds specifically to a single stoichiometric site in MOB1, altering MOB1 structure. Alexis N. Williams, Zeinab Haratipour, Lucia Rameh and Raymond D. Blind

8:50 am  Dnf1 and Dnf2 localization to the plasma membrane requires retromer. Jimenez, M., Best, J.B., Kyoung, C., and Graham, T.R.

9:05 am  Histone Deacetylases Regulate the Glycerol Transporter, Aquaporin-3, in  Human Corneal Epithelial Cells. Melnyk S., Choudhary V., Chen X., and  Bollag W.B.

9:20 am  Mechanisms of Ceramide Synthase Regulation by Small Heat Shock Protein 27 (Hsp27) and Implications in Lethal Mitophagy. Boyd RA, Majumder S., Mavodza G., Stiban J., and Senkal CE 

9:35 am Mechanisms of ORMDL Regulation of Sphingolipid Biosynthesis: Isoform specificity, critical residues, protein turnover. Usha Saraswat Mahawar, Muthu Kumar Kannan, and Brian Wattenberg

9:50 am Break

10:00 am – 11:30 am Oral Session II (Mitchell & Roan)

Lipids and Cellular Physiology 

Session Chairs: Derek Prosser and Prasanna Iyer

10:00 am Ceramide-1-phosphate: a novel regulator of Golgi fragmentation, Golgi-ER vesicle trafficking, and Anaplasma phagocyphilum pathogenesis. Anika N. Ali, Curtis B Read, Daniel J. Stephenson, Chelsea L. Cockburn, Jason A. Carlyon, and Charles E. Chalfant

10:15 am ATP10A has a protective and sex-specific role in lipid metabolism. Norris, A., Yazlovitskaya, E., Zhu, L., Rose, B., Yu, S., McLean, J., Stafford, J.M., Graham,T.

10:30 am Aging-dependent mitochondrial dysfunction mediated by ceramide signaling inhibits antitumor T cell response. Mohamed Faisal Kassir, Silvia Vaena, Paramita Chakraborty, Han Gyul Lee, Alhaji H. Janneh, Gyda Beeson, Zachariah Hedley, Ahmet Yalcinkaya, M. Hanief Sofi, Hong Li, Monica L. Husby, Robert V. Stahelin, Xue-Zhong Yu, Shikhar Mehrotra, and Besim Ogretmen

10:45 am Role of neutral sphingomyelinase-2 in fatty liver disease. Robles-Martinez L., El-Amouri S., Pettey A., Xu H.1, Bieberich E., and Nikolova-Karakashian M.

11:00 am The roles of atypical SPTLC3-derived sphingolipids in cardiac ischemia. Kovilakath A., Mauro A., Devarakonda T., Salloum F., and Cowart L.A.

11:15 am Metabolic Characterization of the Tetrahydrobiopterin Pathway in Brain Tumor Initiating Cells. Tuy K., Tran A., Cooper S., Gordon E., GC S., and Hjelmeland A.

11:30 am Sphingosine Kinase 1 Function in Adipocyte Beiging and Thermogenesis. Yolander Valentine, Bi Ni, Francesco Celi, Sarah Spiegel, L. Ashley Cowart

11:45 am – 12:45 pm  Keynote Presentation (Virtual - Mitchell & Roan) 

Bruce Levy, MD, Harvard Medical School

Title: Roles for Specialized Pro-Resolving Mediators in  Catabasis in Lung Health and Disease

12:45 pm – 1:45 pm  Lunch (Pisgah & Pilot)

1:45 pm – 4:00 pm Free time

4:00 pm - 6:00 pm Poster Session (Pisgah & Pilot)

6:00 pm – 6:15 pm  Awards ceremony (Mitchell & Roan)

6:15 pm – 6:30 pm Presentation of the Lina Obeid Young Scientist Award 

Ashley Cowart, Ph.D., Virginia Commonwealth University

6:30 pm – 7:00 pm Lina Obeid Young Scientist Award Lecture

Alexis Williams, Ph.D., Vanderbilt University

Title: Integrative structural biology reveals bile acids  regulate gut Norovirus capsid dynamics in infection and  immune system evasion

7:00 pm – 8:00 pm SERLC Banquet (Pisgah & Pilot)

8:00 pm – 11:00 pm Social and free time

7:00 am - 8:00 am Breakfast (Pisgah & Pilot)

8:05 am – 10:00 am Oral Session III (Mitchell & Roan)

Lipidomics and Advances in Lipid Technology and Therapeutics 

Session chairs: Can Senkal and Cynthia Weigel 

8:05 am Targeting the Sphingolipid Balance via Acid Ceramidase Inhibition to Decrease Growth of TMZ-Resistant Glioblastoma and Block Migration. Hawkins C.C., Jones A.B., Ziebro J.K., Gordon E.R., Libby C.J, Williford S.E., Allegood J., Cooper S.J., Ramanadham S., Doan N., and Hjelmeland A.B.

8:20 am Liver transcriptome alterations in CerS6 KO mice. Barron K., Krupenko N.

8:35 am Therapeutic Modulation of Mitochondrial Bioenergetics via Ceramide Delivery in Chronic Lymphocytic Leukemia. Vass L., Fox T., Fisher-Wellman K., Costa-Pinheiro P., Jayappa K., and Kester M.

8:50 am High-Resolution Secondary Ion Mass Spectrometry (SIMS) Imaging of Intracellular Lipid Distributions. Gorman B.L., and Kraft M.L.

9:05 am  Pro-resolving Hydrogels Promote Wound Healing After Tissue Transplant. Pittman FS., Sok MCP., and Botchwey EA.

9:20 am C16-pyridinium ceramide and chemotherapeutics cooperate in suppressing cancer cell growth. Hall M.S., Jeffries K., Krupenko N.

9:35 am The Effects of the Fatty Acid Transport Protein (FATP) Inhibitor Grassofermata on Fatty Acid Uptake in Trypanosoma brucei. Kristina M. Parman, Mufida Ammar, and Kimberly S. Paul

9:50 am Function of ceramide transfer protein for biogenesis and sphingolipid composition of extracellular vesicles. Simone M. Crivelli, Caterina Giovagnoni, Zhihui Zhu, Priyanka Tripathi, Ahmed Elsherbini, Zainuddin Quadri, Liping Zhang, Branislav Ferko, Dusan Berkes, Stefka D. Spassieva, Pilar Martinez-Martinez, Erhard Bieberich

10:05 am – 10:15 am Break

10:15 am – 12:30 pm Oral Session IV (Mitchell & Roan)

Lipids in Inflammation and Disease 

Session chairs: Alexis Williams and Yao Zhang

10:15 am Development of Exhausted Memory Monocytes and Underlying Mechanisms. Kisha Pradhan, Ziyue Yi, Shuo Geng, Liwu Li 

10:30 am Sphingosine Kinase 2 Regulates Non-Cell Autonomous Tumor Suppression  Functions of p53 in Breast Cancer. Weigel C., Maczis M.A., Palladino  E.N.D., Green C.D., Maceyka M., Guo C., Wang X.Y., Dozmorov M. G.,  Milstien S., and Spiegel S.

10:45 am Local Modulation of Sphingosine-1-Phosphate Receptor Signaling as a Regenerative Immunotherapy for Volumetric Muscle Loss Injury. Hymel L.A., Anderson S.E., Turner T.C., Ogle M.E., York W.Y., Jang Y.C., Willett N.J., Botchwey E.A.

11:00 am Ceramide kinase regulates acute wound healing and fibroblast function via OXER1-like receptors. Kenneth D. Maus, Daniel J. Stephenson, Anika N. Ali, H. Patrick MacKnight, Minjung Kim, and Charles E. Chalfant

11:15 am Diminished Type I Diabetes in NOD Mice is Correlated to Reduced iPLA2b Expression in T lymphocytes. Tayleur D. White, Ying Gai-Tusing, Charles E. Chalfant, Daniel J. Stephenson, Teresa P. DiLorenzo, Sasanka Ramanadham

11:30 am Pro-survival lipid metabolism activates intracellular complement signaling to induce inflammasome-mediated tumor metastasis. Janneh A.H., and Ogretmen B.

11:45 am Assessing the lipidome and cardiopulmonary exercise parameters in recently decompensated heart failure patients. Wohlford GF., Kovilakath A., Allegood J, Abbate A, Van Tassell BW, Cowart LA

12:00 pm Macrophage iPLA2β-derived Lipids (iDLs) Contribute to Type 1 Diabetes Incidence. Abdulaziz Almutairi, Tayleur D. White, Xiaoyong Lei, Eric S. Ubil, Daniel J. Stephenson, Ying Gai Tusing, Charles E. Chalfant & Sasanka Ramanadham

12:15 pm – 12:30 pm Business meeting

12:30 pm – 1:30 pm Lunch (Pisgah & Pilot)

1:30 pm  55th SERLC adjourned